Facile construction of peptidomimetics by sequential C-S/C-N bond activation of Ugi-adducts
نویسندگان
چکیده
A novel selectively sequential C-S/C-N bond activation is presented. Through the combination of an Ugi-4CR and cleavage, diverse peptidomimetics containing a primary amide are prepared in a...
منابع مشابه
Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions
Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a hydrazinolysis or hydrolysis reaction and subsequent hydrazino-Ugi reaction or classical Ugi reaction for the construction of acyclic acylhydrazino-peptom...
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ژورنال
عنوان ژورنال: Organic chemistry frontiers
سال: 2021
ISSN: ['2052-4110', '2052-4129']
DOI: https://doi.org/10.1039/d1qo01438b